Abstract
Placenta extract has been used as a component of ointments for skin dryness and beautification. However, little is known about the effect of oral intake of placenta extract on skin condition. The current study aimed to clinically explore the effect of oral intake of porcine placenta extract on human skin quality. A randomized controlled double-blind trial was performed on healthy women aged 40–59 years (n = 20), who were randomly assigned to receive either placebo or 200 mg of porcine placenta extract once daily for 4 weeks from 28 January 2019 to 25 February 2019. Skin quality parameters and the Simplified Menopausal Index (SMI) were assessed at baseline and after 4 weeks. After 4 weeks, three parameters of skin quality were significantly improved in the porcine placenta group compared with the placebo group. These results suggest that porcine placenta extract can be used as a health food ingredient to maintain humans’ skin condition in the dry winter season.
Highlights
The placenta is a temporary organ in the females of mammals during gestation that connects the developing fetus via the umbilical cord to the uterine wall
These results suggest that oral intake of placenta extract, which includes bioactive peptides, may improve human skin hydration and elasticity and reduce wrinkling
We explored the effect of oral intake of porcine placenta extract on human skin
Summary
The placenta is a temporary organ in the females of mammals during gestation that connects the developing fetus via the umbilical cord to the uterine wall. It is considered a reservoir of cytokines, hormones, bioactive peptides, enzymes, growth factors, vitamins, and minerals [1]. Benefits of the topical use of porcine placenta extract on chronic and non-healing wounds have been reported [4,5]. Porcine placenta extract has been shown to reduce the wound healing time and increase FGF and TGF levels in rat skin [6]
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