Effect of porcine circovirus type 2 (PCV2) vaccination on PCV2-viremic piglets after experimental PCV2 challenge.

Hwi Won Seo,Chanhee Chae,Kiwon Han,Changhoon Park

doi:10.1186/1297-9716-45-13

Hwi Won Seo, Chanhee Chae + Show 2 more

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https://doi.org/10.1186/1297-9716-45-13

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Journal: Veterinary research	Publication Date: Feb 2, 2014
Citations: 48	License type: cc-by

Affiliation: Seoul National University

Abstract

The objective of this study was to evaluate the effect of porcine circovirus type 2 (PCV2) vaccines on PCV2-viremic and -seropositive piglets born from naturally PCV2-infected sows against postnatal PCV2 challenge. The experimental design was aimed at mimicking commercial swine rearing conditions to evaluate the response of the PCV2 vaccine on PCV2-viremic and -seropositive piglets after experimental PCV2 challenge. PCV2a (or 2b)-viremic piglets received a PCV2 vaccine at 21 days of age followed by a PCV2b (or 2a) challenge at 49 days of age (28 days post vaccination). The PCV2 vaccines elicited a high level of humoral (as measured by immunoperoxidase monolayer assay and neutralizing antibody titers) and cellular (as measured by the frequency of PCV2-specific interferon-γ-secreting cells) immune response in the PCV2-viremic piglets after vaccination even in the presence of maternally derived antibodies (MDA). The initial infection of PCV2 in the pigs was not affected by PCV2 vaccination, however the challenging PCV2 was reduced by PCV2 vaccination on PCV2-viremic pigs. The results from this study demonstrate that the PCV2 vaccine used in this study is effective at reducing PCV2 viremia and lymphoid PCV2 DNA, even for PCV2-viremic pigs with passively acquired MDA at the time of vaccination.

Highlights

Porcine circovirus type 2 (PCV2), a small, non-enveloped, single stranded circular DNA virus belonging to the genus Circovirus of the family Circoviridae [1], is the causative agent of several diseases and syndromes, collectively referred to as porcine circovirus-associated disease (PCVAD) [2]
The PCV2-viremic and -seropositive pigs used in this study had similar PCV2 viremia and serological profiles to naturally infected piglets
Field data indicate that PCV2 vaccines are not inhibited by maternally derived antibodies (MDA) when efficacy is assessed in terms of the reduction of PCV2-associated lesions and viral load in the serum [23,25]

Summary

Introduction

Porcine circovirus type 2 (PCV2), a small, non-enveloped, single stranded circular DNA virus belonging to the genus Circovirus of the family Circoviridae [1], is the causative agent of several diseases and syndromes, collectively referred to as porcine circovirus-associated disease (PCVAD) [2]. Among these conditions, postweaning multisystemic wasting syndrome (PMWS) is the most important [3]. Piglets from PCV2-viremic sows were at high risk for developing PCVAD at any time throughout

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