Abstract
Helicobacter pylori(H. pylori) induces gastric ulceration and carcinogenesis by stimulating expression of chemokines including IL-8. Increased level of IL-8 was observed in gastric mucosa of patients infected with H. pylori. We previously showed that IL-8 is regulated by oxidant-sensitive transcription factor NF-kappaB. Polyunsaturated fatty acids such as linoleic acid (LA), alpha-linolenic acids(ALA), and docosahexaenoic acid(DHA) have shown anti-inflammatory action in various cells and tissues. Present study aims to investigate whether polyunsaturated fatty acids such as LA, ALA, and DHA inhibit H. pylori–induced IL-8 expression by suppressing NF-kappaB in human gastric epithelial AGS cells. H. pylori in a Korean isolate (HP99) was treated to stimulate AGS cells with or without treatment of LA, ALA, DHA, or PA (20, 50, 100μM). H. pylori induced a time-dependent expression of mRNA and protein for IL-8 via mediation of NF-kappaB. Treatment with polyunsaturated fatty acids inhibited the expression of mRNA and protein of IL-8 in H. pylori-infected AGS cells in a dose-dependent manner. Anti-inflammatory nutrients LA, ALA and DHA may be beneficial for prevention or treatment of gastric inflammation associated with H. pylori infection. (This study was supported by Brain Korea 21 Project for Food and Nutrition, Yonsei University College of Human Ecology, Seoul, Korea)
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