Effect of Polyphenols (Kolaviron and Quercetin) on Hepatic indices of Testosterone Propionate Induced-Benign prostatic Hyperplasia in Wistar rats

Abstract

This research examined the impact of polyphenols (kolaviron and quercetin) on hepatic indices in Wistar rats with testosterone propionate-induced benign prostatic hyperplasia. Forty-two animals weighing between 250 and 300g were utilized, divided into six groups, each comprising seven animals. Group one served as the normal control and received 0.5ml Canola oil, while group two- six underwent BPH induction via an intraperitoneal injection of 5mg/kg body weight testosterone for four weeks. Following BPH induction, group two got 0.5mL of Canola oil, while groups three, four, five, and six were treated with 150mg/kg body weight Kolaviron, 15mg/kg body weight Quercetin, 150mg/kg body weight kolaviron plus 15mg/kg body weight quercetin and 5mg/70kg body weight finasteride for twenty-eight days. Following the experimental duration, the rats were euthanized, and liver samples were collected for biochemical analyses. BPH induction led to a decrease in liver weight in rats compared to the control group, whereas treatment with Kolaviron, Quercetin, and Kolaviron + Quercetin resulted in an increase in liver weight compared to the BPH group. Moreover, BPH induction elevated hepatic concentrations of ALT, AST, ALP, total protein, albumin, globulin, total bilirubin, and conjugated bilirubin in comparison to the normal control group. Conversely, treatment with KV, QC, and KV+QC decreased the concentrations of ALP, AST, ALT, total protein, albumin, globulin, total bilirubin and conjugated bilirubin compared to the BPH group. In conclusion, our study demonstrated that quercetin and kolaviron significantly reduced the hepatotoxicity in rats induced by testosterone propionate and could be a cheap and non-invasive treatment alternative for hepatic toxicity brought on by benign prostatic hyperplasia in men.