Effect of polyphenol extracts on glutathione peroxidase enzyme activity in conditions of toxic hepatitis

Abstract

In this study, the inhibitory effects of helmar-1 and helmar-2 polyphenol extracts isolated from the helichrysummaracandicum plant on the activity of the antioxidant glutathione peroxides enzymes in a toxic hepatitis model were compared with silymarin.To induce toxic hepatitis, the subcutaneous area of the abdomens of the experimental animals were injected twice a week with a 50% solution of carbon tetrachloride in olive oil at a dose of 1 ml/kg. After an increase in the levels of the enzymes alanine aminotransferase (ALT) and aspartate aminotransferase (AST) were observed in the bloodplasma,which indicates toxic hepatitis, the helmar-1 and helmar-2 polyphenol extracts and silymarin were administered subcutaneously at a dose of 20 mg/kg once daily for 15 days for pharmacocorrection.