Abstract
Purpose: To investigate the effects of polyphenol extract from Zanthoxylum bungeanum Maxim. (ZPPC) on endocrine hormones, monoamine oxidase activity and behavior in a mouse model of climacteric depression.Methods: Institute of Cancer Research (ICR) female albino mice (n = 50) weighing 24 – 26 g (mean wt = 25.0 ± 1.0 g) were randomly assigned to five groups of ten rats each: normal control group, negative control, and ZPPC (50 mg/kg), ZPPC (100 mg/kg) and ZPPC (200 mg/kg) groups. Depression was induced in the mice via oral administration of moclobemide at a dose of 20 mg/kg, and intraperitoneal injection of imipramine (20 mg/kg) 1 h and 30 min, before treatment. Tail suspension, forced swimming and voluntary activity tests were performed on the mice. The activity of monoamine oxidase (MAO) in mouse brain and the levels of endocrine hormones were also determined.Results: Treatment of depressed mice with ZPPC significantly and dose-dependently increased their tail suspension and immobility time (p < 0.05). The activity of monoamine oxidase in the brains of mice in the negative control group was significantly higher than that of normal control mice, but was significantly and dose-dependently reduced by ZPPC treatment (p < 0.05). Similarly, treatment of depressed mice with ZPPC significantly and dose-dependently reduced their serum adrenocorticotropin and corticosterone levels (p < 0.05).Conclusion: The results of this study indicate that ZPPC exerts antidepressant effect via suppression of brain MAO activity.
 Keywords: Climacteric depression, Endocrine hormones, Menopause, Monoamine oxidase, Polyphenols
Highlights
According to World Health Organization (WHO), depression, which has a lifetime prevalence of more than 15 %, may become the second leading cause of death worldwide after cancer [1]
The present study investigated the effects of ZPPC on endocrine hormones, monoamine oxidase activity and behavior in mouse model of climacteric depression
The results of this study showed that the immobility time of mice in negative control group was significantly longer than that of normal control group, but was significantly and dosedependently shortened by ZPPC treatment
Summary
According to World Health Organization (WHO), depression, which has a lifetime prevalence of more than 15 %, may become the second leading cause of death worldwide after cancer [1]. Fifty Institute of Cancer Research (ICR) female albino mice (n = 50) weighing 24 – 26 g (mean weight = 25.0 ± 1.0 g) were purchased from Guangdong Medical Laboratory Animal Center (No 2018C028). They were housed in metal cages in a greenhouse under standard conditions and had free access to standard feed and water in an environment with equal light/dark periods at 25 ̊C and 60 % humidity. The present study investigated the effects of ZPPC on endocrine hormones, monoamine oxidase activity and behavior in mouse model of climacteric depression. Values of p < 0.05 were taken as indicative of significance
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