Abstract
Metformin hydrochloride, polyacrylic acid and β-cyclodextrin were taken for the preparation of spray dried sustained released micro particles in a different ratios. These sustained release micro particles were used for the preparation of tablets. Hardness of tablet increases with increase in concentration of polymer while the percentage friability decreases with increase in polymer concentration in tablet. The encapsulated drug shows better sustained release than the conventional tablet. The kinetics of the dissolution process were studied by analyzing the dissolution data using three kinetic equations—the zero-order equation, the first-order equation and the Hixson–Crowell cube root law equation.
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