Abstract
In this study, the overall morphology of a mixture of two types of pentablock copolymers was studied. Poly(butylene adipate)-polyethylene glycol (PBA/PEG) and poly(diethyleneglycol adipate)-polyethylene glycol (PDEGA/PEG) dendritic copolymers have been prepared by condensation polymerization. PDEGA-PEG and PBA-PEG mixed micelles were synthesized via nanoprecipitation method and the effect of copolymer composition on morphology, stability, drug loading, in vitro release, and mucoadhesion property of nanoparticles was evaluated. It was found that by changing the composition of two pentablocks in the binary mixed micelles, their morphology and their inner structure can be definitely tuned from uniform mixed micelle to multicompartment one. In vitro mucoadhesion and drug release profile of the nanoparticles were investigated and it was observed that mixing of the two copolymers with specific characteristics can provide a useful situation for preparation of nanocarriers with unique properties for practical applications.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
