Effect of polychlorinated biphenyls (Phenoclor DP6) on in vivo protein and RNA synthesis in rat liver.

Abstract

The results obtained from this study indicate that DP6 ingestion increases the protein synthesis in microsomal membrane fraction from rat liver. However, the nature of the relation between DP6 and RNA metabolism is still not clear, Our experimental procedure does not study all types of RNA involved in the protein synthesis mechanism. However, the increased incorporation of3H-orotic acid into the soluble RNA from DP6 fed rats suggests that this fraction participates in the stimulatory effect of DP6 ingestion.