Effect of polychemotherapy on leukocytes under acute lymphoblast leukosis in children

Abstract

Event Abstract Back to Event Effect of polychemotherapy on leukocytes under acute lymphoblast leukosis in children Anatoliy P. Godovalov1*, Olga V. Lebedinskaya2, Nina B. Merzlova2, Irina A. Baranova1 and Artem V. Proskuryakov1 1 Acad. E.A. Wagner Perm State Medical Academy, immunology, Russia 2 Acad. E.A. Wagner Perm State Medical Academy, histology, embriology and cytology, Russia The aim of investigation was the search for toxicity criteria of cytotoxic preparations while using the analysis of blood values’ dynamics following the chemotherapy with cytostatics’ inclusion. The analysis of hematological parameters was carried out in 24 patients at different terms of treatment during the chemotherapy according to AII-MB-2005 protocol. On completion the first course of treatment the sharp decrease in leukocyte number as observed in a day that corresponds to 2-grade hematotoxicity according to WHO’s classification. Thereafter, the parameter elevation was detected that retained to the end of first therapy cycle. During the treatment it was found that the increment in neutrophil content was realized at the expense of the increase in the number of their mature forms. The initial level of peripheral blood blast cells comprised 25% prior to therapy, 7% (3rd day), and 1% (8th day), then all of patients demonstrated 0% that maintained further. Meanwhile the efficient bone marrow hemopoiesis suppression occurred as well. Given that 4% is a standard value and initial background is 89% in average, the amount of bone marrow blast forms was retained at 1,7% level for the 36 days of therapy. All the patients examined after the first course of polychemotherapy (induction of remission) demonstrated the state of hematological remission. Thus, the suppression of bone marrow hemopoiesis under cytostatics’ therapy according to AII-MB-2005 protocol is not excessive and is maintained at the level that allows achieving remission. This work was supported by RFBR grant №11-04-96037r_ural_a and administrative body of Perm Region. Keywords: chemotherapy toxicity, hematological parameters, suppression mechanisms, leukocyte number, bone marrow hemopoiesis Conference: 15th International Congress of Immunology (ICI), Milan, Italy, 22 Aug - 27 Aug, 2013. Presentation Type: Abstract Topic: Immune-mediated disease pathogenesis Citation: Godovalov AP, Lebedinskaya OV, Merzlova NB, Baranova IA and Proskuryakov AV (2013). Effect of polychemotherapy on leukocytes under acute lymphoblast leukosis in children. Front. Immunol. Conference Abstract: 15th International Congress of Immunology (ICI). doi: 10.3389/conf.fimmu.2013.02.00547 Copyright: The abstracts in this collection have not been subject to any Frontiers peer review or checks, and are not endorsed by Frontiers. They are made available through the Frontiers publishing platform as a service to conference organizers and presenters. The copyright in the individual abstracts is owned by the author of each abstract or his/her employer unless otherwise stated. Each abstract, as well as the collection of abstracts, are published under a Creative Commons CC-BY 4.0 (attribution) licence (https://creativecommons.org/licenses/by/4.0/) and may thus be reproduced, translated, adapted and be the subject of derivative works provided the authors and Frontiers are attributed. For Frontiers’ terms and conditions please see https://www.frontiersin.org/legal/terms-and-conditions. Received: 11 Jun 2013; Published Online: 22 Aug 2013. * Correspondence: Mr. Anatoliy P Godovalov, Acad. E.A. Wagner Perm State Medical Academy, immunology, Perm, Russia, AGodovalov@gmail.com Login Required This action requires you to be registered with Frontiers and logged in. To register or login click here. Abstract Info Abstract The Authors in Frontiers Anatoliy P Godovalov Olga V Lebedinskaya Nina B Merzlova Irina A Baranova Artem V Proskuryakov Google Anatoliy P Godovalov Olga V Lebedinskaya Nina B Merzlova Irina A Baranova Artem V Proskuryakov Google Scholar Anatoliy P Godovalov Olga V Lebedinskaya Nina B Merzlova Irina A Baranova Artem V Proskuryakov PubMed Anatoliy P Godovalov Olga V Lebedinskaya Nina B Merzlova Irina A Baranova Artem V Proskuryakov Related Article in Frontiers Google Scholar PubMed Abstract Close Back to top Javascript is disabled. Please enable Javascript in your browser settings in order to see all the content on this page.