Effect of Platelet-Rich Fibrin on The Regeneration Capacity of Bone Marrow Aspirate In Alveolar Cleft Grafting (Clinical and Radiographic Study)

Abstract

The present study aimed to evaluate the enhancing effect of platelet-rich fibrin (PRF) on autogenous bone marrow aspirate (BMA) using in a resorbable matrix for repair of alveolar cleft defects. It was conducted on 12 patients (7 males and 5 females) with unilateral alveolar cleft and oronasal leakage. They divided into two random equal groups (group I and II). In group I, alveolar cleft defect packed with a mixture of PRF, β-Tricalcium phosphate, and BMA, and the same mixture without PRF for group II. Our clinical results revealed that, all patients had uneventful wound healing except some cases in group II. While, densitometric analysis showed a high statistical significant difference between two groups (p=0.011737) at 6 months interval but, at 12 months interval difference was not statistically significant (p=0.142480). Also, volumetric measurements of new bone showed that, there was highly statistical significant difference (p=0.037997) between group I and II at 12 month interval. The present study concluded that PRF may enhance the regeneration capacity of the stem cells when it added to BMA. Thereby, they may accelerate bone regeneration in alveolar cleft defects. Moreover, it may be used as membrane to cover grafted alveolar defect.