Abstract
This study developed the interests of low-methoxyl pectin (LMP) together with plasticizers for the preparation of elastic thin films. The effect of different plasticizer types (glycerol: Gly; sorbitol: Sor; propylene glycol: PG; and polyethylene glycol 300: PEG 300) and concentrations (20–40% w/w) on mechanical and thermal properties of LMP films as well as on in vitro release of indomethacin were evaluated. Without any plasticizer, a brittle LMP film with low tensile strength and % elongation at break was obtained. Addition of plasticizers from 20% to 40% caused reduction in the tensile strength and Young’s modulus values, whereas percent elongation was increased. Forty percent Gly-plasticized and PG-plasticized films were selected to deliver indomethacin in comparison with non-plasticized film. No significant difference in indomethacin release profiles was displayed between the films. The analysis of indomethacin release model indicated that more than one drug release mechanism from the film formulation was involved and possibly the combination of both diffusion and erosion. Even though indomethacin incorporated in non-plasticized film showed similar release profile, Gly or PG should be added to enhanced film flexibility and decrease film brittleness.
Highlights
Nowadays, concern about limited natural resources and environmental degradation is increasing.A variety of renewable biopolymers has been investigated for development of biodegradable materials to substitute or complement their non-biodegradable petrochemical-based counterparts [1]
When low-methoxyl pectin (LMP) film forming solution was placed onto a solution containing
The films prepared by 3% w/w LMP cross-linked with 3% CaCl2 were homogeneous, transparent with slightly hazy appearance and removed from the plastic cast plates after 10 min of cooling at room temperature
Summary
A variety of renewable biopolymers has been investigated for development of biodegradable materials to substitute or complement their non-biodegradable petrochemical-based counterparts [1]. Bio-based films are made from natural polymers, of animal or vegetable origin, such as polysaccharides, lipids and proteins. When these materials are released into the environment, they are converted into simple compounds that do not harm the bio-system [2]. Numerous studies have been carried out to investigate the properties of biofilms, made from single hydrocolloid components such as polysaccharides or proteins. The most frequently used polysaccharides were celluloses and starch (and their derivatives), chitosan, seaweed extracts (carrageenans and alginates), exudate (arabic gum), seed (guar gum) or microbial fermentation gums (xanthan and gellan gum), and pectin [3]
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