Abstract
A direct action of pituitrin and pitressin on the tissue cells so as to render them incapable of taking up oxygen was one of the possible explanations suggested by Geiling and DeLawder for the significant metabolic changes produced in man and animals by these drugs.1, 2, 3 To test the validity of this suggestion the present work was carried out.Ahlgren4 using Thunberg's methylene blue method found that minute concentrations of various posterior pituitary preparations increased tissue respiration. Himwich, Finkelstein and Humphreys,5 working with the Warburg apparatus, showed on the other hand that the oxygen consumption of excised tissues of white rats is definitely decreased under the influence of pituitrin and pitressin. However, the doses used by them were entirely disproportionate to the amounts generally employed in the intact animal. Accordingly, similar experiments have been carried out with dosages covering a range to include large and small concentrations of post-pituitary preparations (pitressin...
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