Effect of pioglitazone combined with lifestyle intervention on blood lipid and pressure control effects in patients with metabolic syndrome

Abstract

Objective To investigate the effect of pioglitazone combined with lifestyle intervention on blood lipid and pressure control effects in patients with metabolic syndrome (MS). Methods Sixty- five cases of patients with MS between March 2013 and March 2015 were selected and randomly divided into the observation group (35 cases) and control group (30 cases). The observation group was given pioglitazone combined with lifestyle intervention while the control group was only given lifestyle intervention. The blood lipid and pressure control effects, the effect on insulin sensitivity, the related indexes, including total cholesterol (TC), triacylglycerol (TG), fasting blood glucose (FBG), high density lipoprotein cholesterol (HDL), body mass index (BMI), systolic blood pressure (SBP), diastolic blood pressure (DBP), abdominal circumference and fasting insulin (FINS) and insulin sensitivity index (HOMA-IS) were observed and compared between the two groups. Results After treatment, TC, TG, FBG and BMI levels in the two groups were significantly lower than those before treatment, and the abdominal circumference was significantly smaller than that before treatment (P 0.05). After treatment, the SBP (113.54±18.46) mmHg, DBP (73.73±12.16) mmHg and FINS (17.56±4.23) mU/L of the observation group were significantly lower than those of the control group (P<0.05), while HOMA-IR (-3.53±0.91) was significantly higher than that of the control group (P<0.05). Conclusions Pioglitazone combined with lifestyle intervention can significantly relieve many metabolic abnormalities of MS, significantly control the blood lipid and pressure. It can also significantly increase insulin sensitivity at the same time. Key words: Pioglitazone; Lifestyle; Intervention; Metabolic syndrome; Blood lipid and pressure control