Abstract
To determine whether the previously demonstrated decrease in rat brian myelin after pinealectomy is associated with an abnormality in myelin composition, 92 rat pups were subjected either to pinealectomy or sham-pinealectomy at 4 days of age. These animals, reared in diurnal lighting, were killed at 40 days of age, and their brains were individually subjected to myelin fatty acid analysis. In both sexes, all the significant differences, as determined by multivariate analysis of variance, were found in the long chain fatty acids (chain lengths of 16 carbons or more). It was also observed that in 5 of 6 instances in which a significant difference appeared in both sexes for the same fatty acid, the mean quantity of each of these fatty acids in the pinealectomized animals was neither consistently higher nor lower than the comparable sham-operated mean. These results suggest that neonatal pinealectomy in the rat alters the fatty acid composition of brain myelin.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
