Effect of physical procedures for support load deficiency prevention on the state of the hemostatic system in a seven-day immersion experiment

Abstract

Electromyostimulation and mechanical stimulation of the foot were used to prevent support load deficiency during a seven-day “dry” immersion experiment. Partial tromboplastin time, prothrombin time, prothrombin index, international normalized ratio, thrombin time (TT), as well as the concentrations of fibrinogen, soluble fibrin monomer complexes, D-dimer (DD), and plasminogen (PG), and the activity of antithrombin III (ATIII), protein C (PC), and α2-antiplasmin (AP) were determined. Immersion without any prophylactic procedures (control) did not evoke significant changes in the hemostatic system, but a decrease in ATIII, PS, and PG levels was observed during re-adaptation. Mechanical stimulation of the foot did not have a significant impact on the functioning of the hemostatic system during immersion, while the use of electromyostimulation during immersion promoted an increase in procoagulant and fibrinolytic activity of blood plasma.