Abstract
We compared the parameters related to glucose homeostasis, and liver and muscle proteomes in fluorosis-susceptible (A/J; S) and fluorosis-resistant (129P3/J; R) mice in response to fluoride (F) exposure and exercise. Ninety male mice (45 R-mice and 45 S-mice) were randomized into three groups: (SI; RI) No-F, No-Exercise, (SII; RII) 50 ppm F, No-Exercise, (SIII; RIII) 50 ppm F, Exercise. Overall, mean F concentrations in the plasma and femur were significantly higher in R-mice compared with S-mice. In R-mice, exercise resulted in an increase in F accumulation in the femur. In S-mice, the mean plasma glucose level was significantly higher in Group II compared with Groups I and III. There was an increase in liver proteins involved in energy flux and antioxidant enzymes in non-exercise groups (I, II) of S-mice in comparison with the corresponding groups of R-mice. The results also showed a decrease in muscle protein expression in Group I S-mice compared with their R-mice counterparts. In conclusion, the findings suggest an increased state of oxidative stress in fluorosis-susceptible mice that might be exacerbated by the treatment with F. In addition, fluorosis-susceptible mice have plasma glucose levels higher than fluorosis-resistant mice on exposure to F, and this is not affected by exercise.
Highlights
The importance of fluoride (F) is well recognized by the scientific community
The present study aims to elucidate the complex interplay between genetics and lifestyle factors on the effects of F on glucose homeostasis by assessing alterations in the proteomic profile of the liver and muscles of mice with distinct susceptibilities to the effects of F
It should be noted that trained S mice did not present a significant increase in femur concentrations compared to their counterparts that were only exposed to F, which is in line with our previous study [15] but is different from what was reported by Lombarte et al [13] for Sprague Dawley rats. These results indicate a complex interplay between genetics and exercise in F metabolism, which might impact the relationship between the amount of F
Summary
The importance of fluoride (F) is well recognized by the scientific community This element plays a key role in achieving and maintaining oral health due to its potential to control the development of dental caries lesions. Note: Abstract: We compared the parameters related to glucose homeostasis, and liver and muscle proteomes in fluorosis-susceptible (A/J; S) and fluorosis-resistant (129P3/J; R) mice in response to fluoride (F) exposure and exercise. Mean F concentrations in the plasma and femur were significantly higher in Rmice compared with S-mice. In S-mice, the mean plasma glucose level was significantly higher in Group II compared with
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