Abstract
Aims/Purpose: To investigate the effects of new phosphatidylcholine‐eluting contact lenses (PC‐CL) on dry eye in Rabbit.Methods: 18 New Zealand rabbits were used in this study. Meibomian gland orifices were electrocauterized in the dry eye group. PC‐CL were provided from Neo Vision (Yongin, Korea). Rabbits were fitted with control contact lens on one eye and 0.1% PC‐CL on the other eye or with 0.1% PC‐CL on one eye and 0.3% PC‐CL on the other eye. Tear break‐up time (TBUT), tear osmolarity, and corneal fluorescein staining score (FSS), central corneal thickness (CCT), and conjunctival histology were evaluated.Results: In both dry eye and non‐dry eye group, TBUT was longer and tear osmolarity was lower in 0.1% PC‐CL compared to control lens. Cornea was stained with fluorescein in dry eye group, but not in non‐dry eye group. CCT showed no difference in PC‐CL and control lens on both dry eye and non‐dry eye group. In dry eye group, goblet cell density tended to be slightly higher in PC‐CL compared to control. There was no significant difference in TBUT, tear osmolarity, CCT, FSS, and goblet cell density between 0.1% PC‐CL and 0.3% PC‐CL.Conclusions: PC‐CL stabilized tear film and lowered tear osmolarity in dry eye. Thus, it may reduce dry eye symptoms and contact lens complications in clinical practice.
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