Abstract
Summary Lecithin, added to a solution of 180 mmoles per liter of sodium taurocholate solubilized 0.37 ± 0.01 mmole of cholesterol per mmole of added lecithin, whereas lysolecithin solubilized only 0.20 ± 0.01 mmole of cholesterol per mmole of added lysolecithin. No cholesterol precipitated, however, when the lecithin in a bile salt solution saturated with cholesterol was converted to lysolecithin. Oleic acid, the predominant fatty acid released when egg and bile lecithins are converted to lysolecithins, was found to solubilize 0.10 ± 0.01 mmole of cholesterol per mmole of added oleic acid. Equimolar combinations of lysolecithin and oleic acid added to taurocholate acted synergistically to solubilize 0.37 ± 0.02 mmole of cholesterol, the same quantity of cholesterol solubilized by lecithin.
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