Abstract
One of the well-known causes of hearing loss is noise. Approximately 31.1% of Americans between the ages of 20 and 69 years (61.1 million people) have high-frequency hearing loss associated with noise exposure. In addition, recurrent noise exposure can accelerate age-related hearing loss. Phlorofucofuroeckol A (PFF-A) and dieckol, polyphenols extracted from the brown alga Ecklonia cava, are potent antioxidant agents. In this study, we investigated the effect of PFF-A and dieckol on the consequences of noise exposure in mice. In 1,1-diphenyl-2-picrylhydrazyl assay, dieckol and PFF-A both showed significant radical-scavenging activity. The mice were exposed to 115 dB SPL of noise one single time for 2 h. Auditory brainstem response(ABR) threshold shifts 4 h after 4 kHz noise exposure in mice that received dieckol were significantly lower than those in the saline with noise group. The high-PFF-A group showed a lower threshold shift at click and 16 kHz 1 day after noise exposure than the control group. The high-PFF-A group also showed higher hair cell survival than in the control at 3 days after exposure in the apical turn. These results suggest that noise-induced hair cell damage in cochlear and the ABR threshold shift can be alleviated by dieckol and PFF-A in the mouse. Derivatives of these compounds may be applied to individuals who are inevitably exposed to noise, contributing to the prevention of noise-induced hearing loss with a low probability of adverse effects.
Highlights
Hearing loss impairs individuals’ communication, comprehension, and quality of life
Radical STcahveernagdinicgaAl-sctciavviteynogfinDgieackcotilvaintyd oPfFPFF-AF-A and dieckol increased in a dose-dependent Thme raandniecral(-Fsicgauvreen2g)i.nTghaecsteivrietysuoltfsPsFuFg-gAesatntdhadtiedcikecokloinl carnedasPeFdFi-nAalodwoseer-eddeRpeOnSdleenvtels
These results suggest that dieckol and Phlorofucofuroeckol A (PFF-A) lowered ROS levels
Summary
Hearing loss impairs individuals’ communication, comprehension, and quality of life. One of the well-known causes of hearing loss is noise [1]. Noise-induced hearing loss (NIHL) is one of the most common occupational diseases worldwide [2]. Based on the national health and nutrition examination surveys, approximately 12.8% of Americans between the ages of 20 and 69 years have noise-induced hearing threshold shift. NIHL in teenagers has gathered increasing attention [4]. Considering the substantial medical costs, NIHL is an important social, clinical, and economical issue [5]. Two types of NIHL are known: permanent threshold shift (PTS) and temporary threshold shift (TTS). Because of the reversibility of hearing after TTS, previous studies have considered it less important than PTS. A recent study has suggested that TTS can
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