Abstract
AbstractThree parameters have been utilized to assess the performance of combination preparation of betamethasone and phenylephrine hdyrochloride formulated in viscous solutions of methylcellulose, methylhydroxyethylcellulose or polyvinyl alcohol, PVA. The parameters were the area under the curve, AUC, the maximum response, MR, and the,duration of side effect, DA, (increased in the intaocular pressure, IOP). The results demonstrate that balancing the side effect of betamethasone through combination with phenylephrine hydrochloride is highly dependent on the viscosity of the solution to the extent that the effect of the latter is insignificant in aqueous (non viscous) solutions or in a vehicle of a viscosity less than 4 cp (D = 0 sec-1), It was found that PVA seems to be the most powerful one in controlling the side effect of betamethasone.
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