Abstract
Rats were injected with guinea-pig antiinsulin serum and131I-labelled human albumin. The amount of endogenously secreted insulin was estimated from the progressive reduction in the pool of circulating unneutralized antibodies. In animals compelled to swim, insulin secretion occured at a much lower rate than in control rats. Prior injection of phentolamine abolished the exercise-induced inhibition of insulin release. These findings support the concept that such inhibition is dure to endogenously released catecholamines.
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