Abstract
The effects of phenobarbital (PB), polychlorinated biphenyl (PCB) and sodium saccharin (SS) on hepatic and renal carcinogenesis induced by N-ethyl-N-hydroxyethylnitrosamine (EHEN) were examined in male F344 rats. The rats were given 0.1% EHEN in their drinking water for 2 weeks and then diet containing 0.05% PB, 0.05% PCB or 5% SS for 32 weeks. In week 3, the right kidney was removed to promote renal neoplasia. The incidence of hepatocellular carcinoma was much higher in rats given PB or PCB than in controls given EHEN alone. PB administration significantly decreased the average number of renal-cell tumors per unit area and SS reduced the numbers of early neoplastic nodules. Treatment with PCB had no effect on renal carcinogenesis. These results indicate that chemicals may have either a promotive or inhibitory effect depending on the organ.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
