Abstract
Thirteen patients with Dubin-Johnson syndrome were treated with phenobarbital. Phenobarbital significantly decreased the levels of total and direct bilirubin in plasma and there was a significant elevation of the transport maximum of sulfobromophthalein. However, the effect was variable and it appears that some patients did not respond to phenobarbital administration. There was no effect of phenobarbital on the abnormal excretion of urinary corproporphyrin and on factor VII level in the plasma of patients with Dubin-Johnson syndrome. Our findings lent further support to the fact that phenobarbital not only induces enzymes involved in hepatic drug metabolism, but also enhances biliary excretion of various comDounds.
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