Abstract
Titanium alloys are widely employed for the fabrication of biomedical devices. In this study, we designed and developed a Ti-5Al-2.5Cu alloy, which exhibited antibacterial properties. Microstructure and elemental analyses were performed using X-ray diffraction (XRD), scanning electron microscopy (SEM), energy dispersive X-ray spectroscopy (EDS), and transmission electron microscopy (TEM). We evaluated the alloy’s antibacterial properties using Escherichia coli in the plate-count method. The cytotoxicity was examined using the MG-63 cell response by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide (MTT) and lactate dehydrogenase (LDH) assays. Microstructural analysis revealed that Ti-5Al-2.5Cu exhibited an equiaxed α’ martensite structure after short-term annealing. The heterogeneous and homogeneous α → α + Ti2Cu phase transitions occurred at ~840 and 920 °C, respectively. The antibacterial property for Ti-5Al-2.5Cu was varied by volume fraction in the Ti2Cu and Cu-rich phase, which was obtained using different heat treatments. The high volume fraction of the Ti2Cu and Cu-rich phase was observed after long-term annealing at 720–840 °C and thus exhibited a higher antibacterial rate. The relationship between phase distribution and the antibacterial property could be satisfied by a positive linear regression equation. Cytotoxicity results showed that heat treatments at different temperatures for Ti-5Al-2.5Cu alloys had no effect on cell viability. The optimal heat treatment for Ti-5Al-2.5Cu alloy was annealing at 760 °C for 24 h. After, the alloy exhibited both promising antibacterial performance and good cytocompatibility.
Highlights
Titanium and titanium alloys (Ti and Ti alloys) possess superior biocompatibility and high specific strength [1,2,3]
Martensite and some precipitates formed at the boundaries
No significant difference was observed in the scanning electron microscopy (SEM) micrographs of the Ti-5Al-2.5Cu alloy when treated for 1 h at different temperatures
Summary
Titanium and titanium alloys (Ti and Ti alloys) possess superior biocompatibility and high specific strength [1,2,3] These alloys are widely applied for the fabrication of biomedical devices. Because of its poor mechanical properties, the content of oxygen in titanium is used to improve the mechanical properties, and the alloy is graded as G1 to G4 pure Ti. the Ti-Al-V alloy series such as Ti-6Al-4V (Ti-64) alloys have been widely applied for the fabrication of specific biomedical materials because of their excellent mechanical properties, especially when compared with those of CP-Ti. An additional 3–6% Al is considered to enhance the mechanical properties of pure Ti. An additional 3–6% Al is considered to enhance the mechanical properties of pure Ti Some alloys such as Ti-15Mo-5Zr-3Al (mass%) [6] and Ti-5Al-2.5Fe [7]
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
