Abstract
The metabolic effects of rT3 and its role in regulating the metabolic activity of T4 by altering the peripheral monodeiodination of T4 to T3 was studied in normal and thyroidectomized (Tx) rats constantly infused through indwelling atrial catheters. The infusion of 100 μg rT3/100 g BW in normal rats decreased the conversion of T4 to T3 by liver homogenates by 50% (P < 0.001), decreased serum T3 by 21% (P < 0.001), increased serum T4 by 21% (P < 0.001) and had no effect on serum and pituitary GH concentrations. Tx rats were infused with saline, rT3 (100 μg/100 g BW), T4 (2–5 μg/100 g BW), T3 (1 μg/100 g BW), T4 plus rT3, and T3 plus rT3. The infusion of rT3 had no effect on serum and pituitary TSH and GH concentrations. T4 infusion in the Tx rat increased the low in vitro hepatic T3 generation observed in hypothyroidism, decreased serum TSH, increased serum and pituitary GH, and restored the metabolic effect of GH on the epididymal fat pad. The simultaneous infusion of rT3 and T4 partially blocked the meta...
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