Abstract
The effects of pH on the rate and products of malate oxidation by isolated cauliflower bud mitochondria are described. Between pH 6·0 and 7·0 pyruvate is the major product of the oxidation and the rate of oxidation increases with increasing pH. Similar increases in α-oxoglutarate and succinate oxidation rates occur and a general effect of pH on mitochondrial electron transport is indicated. Between pH 7·0 and 8·0 a switch in the major product of malate oxidation from pyruvate to oxaloacetate occurs and the oxidation becomes subject to a strong product inhibition. This change over in products is interpreted in terms of the pH-activity profiles of mitochondrial malate dehydrogenase and NAD requiring malic enzyme.
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