Abstract
In this investigation, tailored mesoporous L-lysine-bioactive glass (LBG) hybrid xerogels were first time synthesized by bioinspired method at ambient conditions. L-lysine molecules were incorporated in bioactive glass (BG) network through physiochemical interaction. Its step-wise addition of various BG precursors with L-lysine took place at its three pKa (2.18, 8.94, 10.54) and pI (9.74) values respectively. These LBG hybrid xerogels were thoroughly characterized before and after interaction with simulated body fluid (SBF). Interestingly, elemental analysis on xerogels reported 45S5 composition for inorganic contents of LBG_8.94 and LBG_9.74. In contrast, LBG_2.18 and LBG_10.54 contained higher SiO2 and corroborating discrete bioactivity behaviour of xerogels. Nitrogen sorption analysis confirmed the mesoporous nature of all four LBG xerogels with different pore size, pore volume and surface area. Importantly, observed unique controlled 7-Dehydrocholesterol release pattern of each LBG xerogels highlighted the importance of their tuneable textural property. Reported viscoelastic nature of freshly prepared LBG xerogels by rheological analysis promised its non-invasive injectability. These new generation materials not only promise to serve nutrients for cell growth but also contain tailored textural as well as rheological properties for targeted bone engineering applications.
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