Abstract
In experiments on single nodes of Ranvier of isolated frog nerve fibers a decrease in pH of the medium to 5 caused a small increase in after-depolarization but an increase in pH to 9 caused virtually no change in it. The after-hyperpolarization arising in potassium-free Ringer's solution was abolished by a decrease in pH but remained substantially unchanged as a result of an increase in pH; posttetanic hyperpolarization was reduced in amplitude and slightly increased in duration by a decrease in pH, but not appreciably changed by an increase in pH. It is concluded that the character of changes in after-potentials of single nodes of Ranvier of isolated nerve fibers in medium of different pH is entirely determined by the influence of this factor on the kinetics of the potassium permeability of the excitable membrane.
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