Abstract
The lipid bilayer bending modulus, characterized by thermal undulations, is often affected by the presence of membrane active molecules. However, complex interplay between headgroup charges, hydration, and bilayer structural parameters such as bilayer thickness make it difficult to understand the changes in bending modulus. Using neutron spin-echo measurements, the effect of ibuprofen, a model nonsteroidal anti-inflammatory drug, on the bending modulus of phospholipid membranes is studied as a function of pH and temperature. Ibuprofen was found to lower the bending modulus at all pH values. We present molecular insights into the observed effect on membrane dynamics based on molecular dynamics simulations and small-angle neutron scattering based structural perturbations as well as changes in zwitterionic headgroup electrostatics due to pH and addition of ibuprofen.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.