Abstract
Effect of Peyer’s patch (PP) excision on immunocompetent cells was evaluated in rats in order to elucidate the role of Peyer’s patch in intestinal immune response. The number of lymphocyte transported through intestinal lymph was significatly decreased after PP-deprivation. IgA containing cell number was remarkably decreased in intestinal mucosa, while other immunoglobulin classes or lymphocyte subpopulation was not significantly altered. When specific immne response against cholera toxin(CT) was examined, anti-CT immunoglobulin A secreting cells in intestinal lymph by ELISPOT assay and anti-CT antibody containing cells in intestinal mucosa were significantly suppressed after PP-deprivation.
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