Abstract
The current study demonstrates the importance of exposure of man-made extrinsic factors, chemicals, pesticides on the human health, reproductive life, and patterns of conception and context of pregnancy in India. Significantly higher levels of pesticides with endocrine disrupting potential in cases indicate the possible role of these compounds as one of the causes of pregnancy loss in exposed female. Possibly, increased pesticide level appears to indicate increased levels of oxidative damage that has been associated with possible cause of recurrent miscarriage (RM), it may reflect indirect evidence of toxicity rather than direct cause. Further epidemiological studies with larger cross-sectional population need to be performed to clearly elucidate the role of endocrine disruption, polymorphism in metabolic susceptibility genes and genetic environmental interaction in association with reproductive life. This might be helpful in identifying subpopulation/individuals at higher risk.
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