Abstract
The article provides information on the effect of pesticides - butylcaptax and droppa on respiration and oxidative phosphorylation of liver mitochondria in rat rats and their embryos. It has been shown that butylcaptax and droppa reduce the oxidation of succinate and α-ketoglutarate in the V4*, V3 and Vdnf states and drug conjugation in the liver mitochondria of pregnant animals and their embryos. The most significant inhibition of ADF formation in the respiratory chain of fatal and maternal liver mitochondria occurs via the NAD-dependent pathway, especially when poisoning with butylcaptax on the 19th day of pregnancy. Apparently, inhibition of ADF-stimulated respiration is associated with inhibition of electron transfer along the respiratory chain or is a consequence of inhibition of the transport of phosphate or ADF into mitochondria, which plays a key role in the mechanism of oxidative phosphorylation. A decrease in the conjugation of oxidation and phosphorylation does not create conditions for the accumulation of energy in an utilizable form - in the form of ADF.
Highlights
The accumulation of toxic chemicals in the body of pregnant women is extremely dangerous
In connection with the above, we studied the effect of butylcaptax and droppa on the oxidative phosphorylation systems in the liver mitochondria of pregnant rats and their embryos
Data on the effect of butylcaptax and droppa on respiration and oxidative phosphorylation in the mitochondria of the liver of embryos and the maternal organism on the 3rd, 13th and 19th days of pregnancy are presented in Figures 1 and 2
Summary
The accumulation of toxic chemicals in the body of pregnant women is extremely dangerous. Regardless of whether the damaging agents act directly on the mitochondrial membranes or this effect is mediated by intermediate factors, membranes react subtly to the action of chemical agents by changing the structural characteristics and activity of membrane-bound enzymes. The most important component of the differentiation of the structure and functions of the liver is the formation of physiological, biochemical functions and mechanisms of their regulation. The study of these processes is necessary to understand the causes of deviations during the period of individual development of the organism and to develop methods for treating pathologies
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