Abstract
Administration of pertussis vaccine to rats markedly diminished the sensitivity of their vascular α 2-adrenoceptors as evidenced by shifts to the right and decreased maximal pressor responses to clonidine and azepexole in pithed rats. No effect was observed on the sensitivity of α 1-adrenoceptors as evidenced by the dose-response curve to methoxamine. A slight persistent tachycardia was also produced by the vaccine. A model to explain the effects of the vaccine on the vascular system of the rat is proposed.
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