Abstract

Perivascular sympathectomy has been used for the treatment of vasospastic disorders of the hand, with the idea that it causes distal adrenergic denervation. In this study perivascular sympathectomy was performed at the base of the central ear vessels on the left side in eight rabbits. The vessels on the right side were used as controls. The noradrenaline content of the vessels, examined by high performance liquid chromatography (HPLC) with electrochemical detection two days after the operation, was significantly lower in the distal vasculature on the operated side than on the control side (P < 0.0001) although still markedly higher than at the sympathectomy site itself (P < 0.0001). Thus the operation seems to cause partial but not total denervation of the distal adrenergic nerves.

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