Effect of Peritoneal Dialysis and a Single Hemodialysis on Erythrocyte Membrane Atpase Activity of Uremic Subjects

Abstract

In this study erythrocytic A TPase activities were studied in 21 patients before and after six hours of hemodialysis. In another group of 20 patients A TPase activities were also studied before and after 48 72 hours of peritoneal dialysis. As a control group 20 healthy normal subjects were used. Comparison of the results revealed that all three (Na+/k+, Mg++, Ca++/Mg++) ATPase activities were lower in the chronic renal failure patients than normal controls (p < 0.001). Both peritoneal and hemodialysis increased significantly all three A TPase activities. When peritoneal and hemodialysis results were compared no significant difference was noted. It is concluded that the increase in A TPase activites observed by both dialysis methods is due to removal from the plasma of substances which are responsible for the decrease in A TPase activities before dialysis. In uremia numerous substances alone or together have been held responsible for various clinical findings. In addition some other metabolic wastes of unknown structure act upon important enzyme systems resulting to an altered cellular function. A TPase enzymes are a group of enzymes responsible for the maintenance of the ionic and osmotic balance of the cells. In this study we studied the status of these enzymes in ESRD patients undergoing dialysis and also the acute effect of peritoneal dialysis and hemodialysis on them.