Effect of periodontal therapy on adipokine biomarkers in overweight.

Abstract

The aim of this study was to evaluate the effect of non-surgical periodontal therapy on circulating levels of the systemic inflammation-associated biomarkers orosomucoid (ORM), high-sensitivity C-reactive protein (hsCRP), chemerin, and retinol-binding protein 4 (RBP4) in overweight or normal-weight patients with periodontitis at 27.5months after therapy. This exploratory subanalysis includes patients from the ABPARO-trial (ClinicalTrials.gov NCT00707369). The per-protocol collective provided untreated periodontitis patients with high (≥28kg/m2 ) or moderate (21-24kg/m2 ) BMI. Out of the per-protocol collective, 80 patients were randomly selected and stratified for BMI group, sex, and treatment group (antibiotics/placebo), resulting in 40 overweight and normal-weight patients. Patients received non-surgical periodontal therapy and maintenance at 3-month intervals. Plasma samples from baseline and 27.5months following initial treatment were used to measure the concentrations of ORM, hsCRP, chemerin, and RBP4. At the 27.5-month examination, ORM and hsCRP decreased noticeably in the overweight group (ORM: p=.001, hsCRP: p=.004) and normal-weight patients (ORM: p=.007, hsCRP: p<.001). Chemerin decreased in the overweight group (p=.048), and RBP4 concentrations remained stable. Non-surgical periodontal therapy reduced systemically elevated inflammation-associated biomarkers in periodontitis patients. These improvements were more pronounced in overweight patients than in normal-weight patients.