Effect of perindopril combined with candesartan on oxidative stress injury and cardiac function in patients with chronic heart failure

Abstract

Objective To observe the effect of perindopril and candesartan combined treatment on oxidative stress injury and cardiac function in patients with chronic heart failure (CHF). Methods 92 patients with CHF treated in our hospital from November 2015 to October 2016 were selected as the research object, and were divided into two groups with the random number table method, 46 cases in each group. The control group was treated with perindopril, and the observation group was treated with candesartan on the basis of the control group. The indexes of oxidation and cardiac function were observed before and after treatment in the two groups. Results There were no statistically significant differences in the levels of malondialdehyde (MDA) and superoxide dismutase (SOD) between the two groups before treatment (P>0.05); after treatment, the levels of MDA and SOD in the observation group were better than those in the control group, with statistically significant differences (P 0.05); after treatment, the levels of LVEF, LVDd, LVDs in the observation group were better than those in the control group, with statistically significant differences (P<0.05). Conclusion Perindopril combined with candesartan is effective in the treatment of CHF, which is beneficial to improve cardiac function and reduce oxidative stress injury, of high value in clinical practice. Key words: Perindopril; Candesartan; Chronic heart failure; Oxidative stress injury; Cardiac function