Effect of percutaneous kyphoplasty vs.open reduction and internal fixation on lumbar biomechanical function of adjacent vertebrae in rabbits with osteoporosis

Abstract

Objective To research the changes of lumbar biomechanical function of rabbit model after open reduction and internal fixation and percutaneous kyphoplasty(PKP). Methods New Zealand rabbits were ovariectomized to establish osteoporosis through model, model was successful in 42 cases, divided into two groups, 21 rats in group A, be for open reduction and internal fixation operation,21 rats in group B underwent PKP operation, to observe the changes of the two groups, the model of vertebral compression bending and maximum load experiment content,change of bone mineral density(BMD),change of average height and the sagittal Cobb angle of the vertebral body after operation. Results Two groups of rabbit model after PKP(group B) and open reduction and internal fixation operation(group A), the vertebral bearing pressure ability has been significantly improved compared with before operation, the difference was statistically significant(P 0.05), 18 months after the operation of anterior vertebral height by the average preoperative(38.81±4.12)% and(80.17±8.38)% recovery percent in group B, sagittal Cobb angle by preoperative(30.13±4.27)°recovered to the(8.69±2.41)°.Group B with BMD, vertebral height and Cobb angle measurement value changes compared with the group A, the difference has statistical difference(P< 0.05). Conclusion Compared with open reduction and internal fixation operation, PKP can better improve vertebral body and adjacent vertebral kyphosis angle,significant bearing pressure, PKP is safe and effective in the treatment of osteoporosis, worthy of promotion. Key words: Open reduction and internal fixation; Percutaneous kyphoplasty; Vertebral fracture; Biomechanics; Rabbit