Abstract
Objective: To investigate the effect of peptide YY (PYY) on the flow of splanchnic blood and bile in dogs. Methods: Under general anaesthesia, the dogs received porcine PYY at doses of 100, 400, or 800 pmol/kg/h for 1.5 h. Blood flow was measured in the subserosa of the jejunum, ileum, and colon as well as in the liver, using the hydrogen gas clearance method, before, during, and after PYY infusion. Choledochal bile was collected and its volume measured. Results: Colonic blood flow was significantly inhibited by 100, 400, and 800 pmol/kg/h PYY compared with the pre-infusion levels (P < 0.05, P < 0.05, and P < 0.01, respectively). It was also inhibited by 800 pmol/kg/h PYY (P < 0.05) compared with the non-infusion group
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