Abstract
We investigated effects of peptide therapy on the lung tissue remodeling in a rat model of chronic obstructive pulmonary disease (COPD) using histological, morphometric and immunohistochemical methods. The rats were exposed to nitrogen dioxide during 60 days. One-month course of peptide therapy has led to reduction in hyperplasia and muscle hypertrophy, recover of bronchial epithelium squamous metaplasia, and decrease in T- and B-lymphocyte number. In treated rats, foci of alveolar hyperextension and irregular emphysema, that were typical for untreated animals with COPD, were small and found only in subpleural areas. There results suggest therapeutic influence of low molecular peptides on the lung disease related to toxic inhalation.
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