Abstract
The administration of large doses of penicillin for twenty-four hours prior to dental extraction caused a significant decrease in incidence of bacteremia following extraction but failed to prevent it in a large number of cases. The agent was particularly effective in decreasing bacteremia after extraction of teeth from infected gums. The possible modus operandi of prophylactic penicillin in preventing subacute bacterial endocarditis is suggested and the recommendation made that this agent be given to all patients with rheumatic and congenital heart disease before and after dental extraction.
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