Abstract
Cell membrane dysfunction due to loss of structure integrity is the pathology of tissue death in trauma, muscular dystrophies, reperfusion injuries and common diseases. It is now established that certain PEG-based biocompatible polymers, such as Poloxamer 188, Poloxamine 1107 and PEG, are effective in sealing of injured cell membranes, thus can prevent acute necrosis if delivered timely after injury. Despite these broad applications of PEG-based polymers for human health, the fundamental mechanisms how PEG-based polymers interact with cell membranes are still under debate.
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