Abstract
This study was conducted to know the effect of pectin on the α-amylase activity in the pancreas, intestine content and blood in growing rats with lead intoxication. After a single oral administration of lead acetate (80 mg/kg) to growing rats pectin was administered (400 mg/kg/12h) for 4 days. It is revealed that the administration of lead acetate causes an increase in pancreas weight, protein content in the pancreas and α-amylase activity in the pancreas and blood and reduced activity of the enzyme in the intestinal cavity in rats. Regular oral administration of pectin has a normalizing effect on pancreatic weight, protein content and on the level of the activity α-amylase in the pancreas, intestinal contents and blood in the 48-72 hours of observation in rats. These results support our suggestion about the possibility of the use of pectin for correcting of pancreatitis similar shifts at lead intoxication.
Highlights
Pectin is heteropolysaccharide consisting of mainly residues of galacturonic acid
In the second experimental group rats received a single oral administration of lead acetate (80 mg/kg body weight), were orally administered pectin (Cargill pectin PG DS, (Germany) in a dose of 400 mg/kg/12 h to end of the experiment
The results showed that the introduction of pectin to intoxicated rats prevents body weight loss caused by administration of a toxic dose of lead acetate
Summary
Pectin is heteropolysaccharide consisting of mainly residues of galacturonic acid. This soluble fiber is present in all higher plants, especially in fruits. Due to its properties pectin swells in the gastrointestinal tract, forming a gelatinous mass that adsorbs undigested food residues, binds and removes cholesterol and other toxic substances and waste products from the body, improves blood circulation and intestinal peristalsis [1,2,3,4]. The acid connects with ions of lead, cadmium, mercury, forming insoluble salts These salts are not absorbed from the cavity of the gastrointestinal tract and excreted with feces [2, 3]
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