Effect of PCSK9 Inhibition on the Plasma Proteome: A SPIRE SubStudy.

Abstract

HomeArteriosclerosis, Thrombosis, and Vascular BiologyAhead of PrintEffect of PCSK9 Inhibition on the Plasma Proteome: A SPIRE SubStudy Open AccessResearch ArticlePDF/EPUBAboutView PDFSections ToolsAdd to favoritesDownload citationsTrack citationsPermissions ShareShare onFacebookTwitterLinked InMendeleyReddit Jump toOpen AccessResearch ArticlePDF/EPUBEffect of PCSK9 Inhibition on the Plasma Proteome: A SPIRE SubStudy Jordan M. Kraaijenhof, Tjerk S.J. Opstal, Jan H. Cornel, Dipender Gill, G. Kees Hovingh, Alberico L. Catapano, Wolfgang Koenig, Paul M Ridker, Erik S.G. Stroes and Nick S. Nurmohamed Jordan M. KraaijenhofJordan M. Kraaijenhof https://orcid.org/0000-0001-7566-6403 Department of Vascular Medicine, Amsterdam University Medical Centers, University of Amsterdam, The Netherlands (J.M.K., G.K.H., E.S.G.S., N.S.N.). Search for more papers by this author , Tjerk S.J. OpstalTjerk S.J. Opstal https://orcid.org/0000-0003-3654-0327 Department of Cardiology, Radboud University Medical Centre, Nijmegen, the Netherlands (T.S.J.O., J.H.C.). Department of Cardiology, Northwest Clinics, Alkmaar, the Netherlands (T.S.J.O., J.H.C.). Search for more papers by this author , Jan H. CornelJan H. Cornel https://orcid.org/0000-0002-1006-2112 Department of Cardiology, Radboud University Medical Centre, Nijmegen, the Netherlands (T.S.J.O., J.H.C.). Department of Cardiology, Northwest Clinics, Alkmaar, the Netherlands (T.S.J.O., J.H.C.). Search for more papers by this author , Dipender GillDipender Gill https://orcid.org/0000-0001-7312-7078 Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, United Kingdom (D.G.). Search for more papers by this author , G. Kees HovinghG. Kees Hovingh https://orcid.org/0000-0002-8145-1676 Department of Vascular Medicine, Amsterdam University Medical Centers, University of Amsterdam, The Netherlands (J.M.K., G.K.H., E.S.G.S., N.S.N.). Search for more papers by this author , Alberico L. CatapanoAlberico L. Catapano https://orcid.org/0000-0002-7593-2094 Department of Pharmacological and Biomolecular Sciences, University of Milan, Milano, Italy (A.L.C.). IRCCS Multimedica, Milano, Italy (A.L.C.). Search for more papers by this author , Wolfgang KoenigWolfgang Koenig https://orcid.org/0000-0002-2064-9603 Deutsches Herzzentrum München, Technische Universität München, Munich, Germany (W.K.). German Centre for Cardiovascular Research (DZHK e.V.), partner site Munich Heart Alliance, Germany (W.K). Institute of Epidemiology and Medical Biometry, University of Ulm, Germany (W.K.). Search for more papers by this author , Paul M RidkerPaul M Ridker https://orcid.org/0000-0003-1249-4522 Divisions of Preventive Medicine and Cardiovascular Diseases, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA (P.M.R.). Search for more papers by this author , Erik S.G. StroesErik S.G. Stroes https://orcid.org/0000-0001-9555-6260 Department of Vascular Medicine, Amsterdam University Medical Centers, University of Amsterdam, The Netherlands (J.M.K., G.K.H., E.S.G.S., N.S.N.). Search for more papers by this author and Nick S. NurmohamedNick S. Nurmohamed Correspondence to: Nick S. Nurmohamed, MD, Departments of Vascular Medicine and Cardiology, Amsterdam UMC, University of Amsterdam, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands. Email E-mail Address: [email protected] https://orcid.org/0000-0001-9045-6009 Department of Vascular Medicine, Amsterdam University Medical Centers, University of Amsterdam, The Netherlands (J.M.K., G.K.H., E.S.G.S., N.S.N.). Department of Cardiology, Amsterdam University Medical Centers, Vrije Universiteit Amsterdam, The Netherlands (N.S.N.). Search for more papers by this author Originally published15 Jun 2023https://doi.org/10.1161/ATVBAHA.123.319272Arteriosclerosis, Thrombosis, and Vascular Biology. 2023;0FootnotesFor Sources of Funding and Disclosures, see page XXX.Correspondence to: Nick S. Nurmohamed, MD, Departments of Vascular Medicine and Cardiology, Amsterdam UMC, University of Amsterdam, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands. Email n.s.[email protected]nl Previous Back to top Next FiguresReferencesRelatedDetails Advertisement Article InformationMetrics © 2023 The Authors. Arteriosclerosis, Thrombosis, and Vascular Biology is published on behalf of the American Heart Association, Inc., by Wolters Kluwer Health, Inc. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution, and reproduction in any medium, provided that the original work is properly cited.https://doi.org/10.1161/ATVBAHA.123.319272PMID: 37317854 Originally publishedJune 15, 2023 Keywordsinflammationproteomicslipid-lowering therapyphenotypecardiovascular diseasePDF download Advertisement SubjectsAtherosclerosisDiagnostic TestingLipids and CholesterolSecondary Prevention