Effect of PCL concentration on PCL/CaSiO3 porous composite scaffolds for bone engineering

Abstract

Porous polycaprolactone (PCL)-coated calcium silicate (CaSiO3) composite scaffolds were successfully prepared by 3D gel-printing (3DGP) and vacuum impregnation technology in this study. The effect of different PCL concentration on porous CaSiO3 scaffolds prepared by 3DGP technology was studied. The composition and morphological characteristics of PCL/CaSiO3 scaffolds were tested by using fourier transform infrared spectroscopy (FTIR), scanning electron microscope (SEM), and energy dispersive spectrometer (EDS) analysis. PCL coating amount on the scaffolds surface was calculated by thermogravimetric analysis (TGA). Compressive strength was tested by a universal testing machine, and degradability was tested by immersing the scaffolds in a simulated body fluid (SBF). The results show that PCL coating thickness increased from 7.29 μm to 12.2 μm, and the compressive strength of the corresponding composite scaffolds increased from 17.15 MPa to 24.12 MPa following with PCL concentration increasing from 7.5% to 12.5%. When the porous composite scaffolds were immersed in SBF for 28 days, the degradation ratio was 1.06% (CaSiO3), 1.63% (CaSiO3-7.5PCL), 1.81% (CaSiO3-10PCL) and 1.55% (CaSiO3-12.5PCL), respectively. It is obviously that PCL/CaSiO3 composite scaffolds, which are suitable for bone growth in bone repair engineering, are beneficial to improve the mechanical properties and biodegradability of pure CaSiO3 scaffolds.