Abstract
Although the adverse effects of maternal aging on reproductive outcomes have been investigated widely, there is no consensus on the impact of paternal age. Therefore, we investigated the effect of paternal age on reproductive outcomes in a retrospective analysis of 9,991 in vitro fertilization (IVF) cycles performed at the Reproductive Medicine Center of the Third Affiliated Hospital of Guangzhou Medical University (China) between January 2007 and October 2013. Samples were grouped according to maternal age [<30 (3,327 cycles), 30–34 (4,587 cycles), and 35–38 (2,077 cycles)] and then subgrouped according to paternal age (<30, 30–32, 33–35, 36–38, 39–41, and ≥42). The groups did not differ in terms of fertilization rate, numbers of viable and high-quality embryos and miscarriage rate when controlling maternal age (P >0.05). Chi-squared analysis revealed that there were no differences in implantation and pregnancy rates among the different paternal age groups when maternal age was <30 and 35–38 years (P >0.05). However, implantation and pregnancy rates decreased with paternal age in the 31–34 y maternal age group (P <0.05). Our study indicates that paternal age has no impact on fertilization rate, embryo quality at the cleavage stage and miscarriage rate. For the 30–34 y maternal age group, the implantation rate decreased with increased paternal age, with the pregnancy rate in this group being significantly higher in the paternal <30 y and 30–32 y age groups, compared with those in the 36–38 y and 39–41 y groups.
Highlights
The age of parenthood has been steadily increasing over recent decades
With nearly 10,000 in vitro fertilization (IVF) cycles included in the present study, we aimed to investigate the influence of paternal age on the reproductive outcomes in IVF cycles in a population of Chinese men
Chi-squared analysis revealed that there were no significant differences in implantation rate and pregnancy rate
Summary
The age of parenthood has been steadily increasing over recent decades. In 2014, the Chinese government implemented an exemption to the one-child policy allowing a second child for families in which one parent, rather than both, is an only-child. Many older couples are deciding to have a second child. The adverse effects of maternal aging on reproductive. Effect of Paternal Age on Reproductive Outcomes of IVF outcomes have been investigated widely, revealing that the pregnancy rate declines with maternal age, while the rates of miscarriage and birth defects increase. The impact of advanced paternal age is comparatively less well-studied and there is no current consensus on its impact on reproduction outcomes
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