Abstract
Two samples of talc powder USP—from different sources—showed remarkable difference, over a wide range of concentrations, in their hiding capacities. Particle size, size distribution and surface area were not adequate to account for the difference in physical behavior of the two samples. Morphological characterization based on Fourier shape descriptors of the particle boundary can better explain the difference. The study suggests that in addition to size parameters, the particle shape is equally important in the quality assurance monographs of pharmaceutical solid excipients.
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