Abstract
The excretion pattern of calcium (Ca), magnesium (Mg), potassium (K), sodium (Na), phosphorus (P) and protein of the parotid saliva was studied before and during PTE administration in 6 normal subjects aged 24 to 32 years. The Stensen's duct was cannulated and the flow rate of saliva measured before and after stimulation by lemon juice. After a control period, 50 U of PTE were given i.v. followed by an infusion of 2 U/min. for 60 to 90 min. In the absence of any change in serum Ca and P, PTE induced a significant increase of salivary Ca (p< 0.001), P (p< 0.005) and protein (p< 0.001) concentrations. These changes were independent of the flow rate. Na excretion was also increased (p< 0.005) but only at high flow rates. PTE had no significant effect on Mg and K concentrations. These results provide evidence that PTE acts on the parotid gland by affecting Ca and P transport and protein secretion.
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