Effect of Paracetamol, Dexketoprofen Trometamol, Lidocaine Spray, and Paracervical Block Application for Pain Relief during Suction Termination of First-Trimester Pregnancy

Evrim Albayrak,Nil Özoğlu,Hüseyin Aksoy,Ülkü Aksoy,Gökhan Açmaz

doi:10.1155/2013/869275

Evrim Albayrak, Nil Özoğlu + Show 3 more

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https://doi.org/10.1155/2013/869275

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Abstract

The aim of the study was to investigate the analgesic efficacy of preoperative oral dexketoprofen trometamol, intravenous paracetamol, lidocaine spray, and paracervical block with ultracaine on curettage procedure. A total of 111 subjects with the request of pregnancy termination between 5 and 7 weeks of gestation were included in the study. The first group (control group) consisted of 20 participants without medication. The second group consisted of 25 participants receiving 2 puffs of lidocaine sprays on cervical mucosa. The third group consisted of 20 participants receiving oral 25 mg dexketoprofen trometamol. The fourth group consisted of 23 participants receiving 1000 mg intravenous paracetamol and the fifth group consisted of 23 participants receiving paracervical block with ultracaine. Paracervical block reduced pain score significantly in both intraoperative and postoperative periods. All analgesic procedures were significantly effective for reducing pain in postoperative period. Paracervical block may be the best method for reducing pain scores in intraoperative and postoperative periods during curettage procedure. All analgesic procedures such as lidocaine, paracetamol, ultracaine, and paracervical block with ultracaine can be used for reducing pain score in postoperative period. This trial is registered with NCT01947205.

Highlights

IntroductionA surgical procedure, is commonly used for the first-trimester pregnancy termination
Curettage, a surgical procedure, is commonly used for the first-trimester pregnancy termination
Blumenthal and Remsburg showed that suction curettage might be performed on an outpatient basis under local anesthesia and cost of patients might be reduced by using suction curettage practice on an outpatient basis [11]

Summary

Introduction

A surgical procedure, is commonly used for the first-trimester pregnancy termination. Known as “paracetamol,” acetaminophen (N-acetyl4-aminophenol), which has analgesic and antipyretic properties and has been widely used as an active ingredient in many approved drugs, is one of the most widely used medicines in the world [3]. It has been shown that paracetamol can be used after gynecologic surgical procedures [4]. The reduced activity of COX-1 is associated with side effects of NSAIDs as gastrointestinal bleeding and platelet dysfunction. Dexketoprofen trometamol, the active enantiomer of racemic ketoprofen, is classified as NSAID with analgesic and antipyretic properties [5]. Api et al showed that curettageassociated pain may be reduced by administration of oral dexketoprofen during fractional curettage [6]

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